5 RESULTS
COMMENT These studies elegantly demonstrate that microglia are able to detect and respond to changes in tissue stiffness via the Piezo1 mechanoreceptor, and that this mechanism is essential for their detection and response to plaques. Furthermore, deletion of Pie
COMMENT This is a compelling study demonstrating the power of ASOs. The authors show ASOs can potently target gene expression within microglia (especially for microglial-enriched genes), allowing for nuanced experiments that have been difficult to perform before.
COMMENT This paper, combined with the Monje lab’s recent Cell paper (Gibson et al., 2018), elegantly highlights the complexity of cellular interactions in toxicity/disease states, and place microglia as the major effector cell type that has broad effects on astro
COMMENT This is a fantastic study with important implications. It illustrates the link between oxygen levels and the production of Aβ—something on which I conducted my Ph.D. over 10 years ago. It also suggests that this effect is probably body-wide, rather than r
COMMENT The current study by Yang et al. shows a novel physiological role for APP in the regulation of the L-type voltage-gated calcium channel specifically in GABAergic neurons. These results highlight APP—and APP fragments—as important regulators of synaptic fu
